Brain-Derived Neurotrophic Factor or BDNF has drawn attention as a possible biomarker to encourage the identification or track the effectiveness of treatments in mental disorders. Circulating BDNF may be quantified in serum, plasma, or whole blood.
On the other hand, the usage of BDNF because biomarker is restricted by the poor reproducibility of results, probably because of the selection of processes used for sample collection and BDNF investigation. A BDNF ELISA equipment quantitates human BDNF in serum, plasma screen, supernatant.
The assay will only recognize both natural and recombinant human BDNF. BDNF is called pre-pro BDNF. Although additional processing generates the mature, protein, pro-BDNF is biologically active and can be secreted in synaptic vesicles together with the elderly form.
BDNF is broadly expressed in the central nervous system also functions in an autocrine and paracrine manner on many types of neurons. Signaling occurs mostly via the tyrosine kinase receptor, though binding to the lower-affinity receptor, p75-NTR, has also been shown. BDNF promotes neuronal survival and differentiation and has been proven to play a crucial role in memory formation and synaptic regulation.
BDNF is triggered by cortical neurons and is vital for the survival of striatal neurons within the mind. Expression of BDNF is decreased in Alzheimer's and Huntington's disease sufferers, and might also play a part in the regulation of stress response and in the research of mood disorders. The protein encoded by this gene is a part of the nerve growth factor family. It's triggered by cortical neurons and is vital for the survival of striatal neurons within the mind.